BIRC2

Across TCGA patient cohorts, BIRC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,166 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible BIRC2-associated GO terms across cancer lineages are COPII-coated vesicle cargo loading, Positive regulation of mRNA processing, and Regulation of vacuole organization. Each is linked with BIRC2 in more than 32 cancer types. Because this analysis shows association rather than direction, both BIRC2-to-partner and partner-to-BIRC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COPII-coated vesicle cargo loading grouped by BIRC2-low versus BIRC2-high in UCS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BIRC2→partner) and Y-score (partner→BIRC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	COPII-coated vesicle cargo loading →	+0.086	+0.528	<.001	<.001	3	33
SCLC	Positive regulation of mRNA processing →	+0.097	+0.681	.001	<.001	3	32
UVM	Regulation of vacuole organization →	+0.073	+1.710	<.001	<.001	3	32
THYM	Regulation of autophagosome assembly →	+0.066	+0.777	<.001	<.001	3	32
UVM	Membrane fission →	+0.078	+1.746	<.001	<.001	3	31
UVM	Nuclear pore complex assembly →	+0.093	+1.746	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,166 associations by consensus.

COPII-coated vesicle cargo loading by BIRC2 expression — UCS

Explore this box plot interactively →