BIRC2

Across TCGA patient cohorts, BIRC2 protein abundance is significantly associated with the RNA expression of many other genes, with 18,901 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible BIRC2-associated genes across cancer lineages are ME3, PHPT1, and C2CD2L. Each is linked with BIRC2 in more than 3 cancer types. Because this analysis shows association rather than direction, both BIRC2-to-partner and partner-to-BIRC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BIRC2 versus ME3 in BRCA, with a Pearson correlation of 0.29.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BIRC2→partner) and Y-score (partner→BIRC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ME3 →	+0.984	+0.193	<.001	<.001	3	4
UCEC	PHPT1 →	+1.254	+0.212	<.001	<.001	3	4
BRCA	C2CD2L →	+0.603	+0.230	<.001	<.001	3	3
HNSC	CYTH1 →	-0.682	-0.162	.005	.006	3	3
BRCA	CEP128 →	-0.386	-0.153	<.001	<.001	3	3
BRCA	HCFC1R1 →	+0.807	+0.198	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,901 associations by consensus.

BIRC2 vs ME3 — BRCA

Explore this scatter interactively →