BIRC2

Across TCGA patient cohorts, BIRC2 protein abundance is significantly associated with the protein abundance of many other proteins, with 28,290 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible BIRC2-associated proteins across cancer lineages are TRAF2, PPP1R13L, and CUL5. Each is linked with BIRC2 in more than 7 cancer types. Because this analysis shows association rather than direction, both BIRC2-to-partner and partner-to-BIRC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BIRC2 versus TRAF2 in LSCC, with a Pearson correlation of 0.33.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (BIRC2→partner) and Y-score (partner→BIRC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TRAF2 →	+0.272	+0.243	<.001	<.001	2	8
LSCC	PPP1R13L →	+0.385	+0.151	<.001	<.001	3	5
BRCA	CUL5 →	+0.284	+0.246	<.001	<.001	3	4
BRCA	GOLGA1 →	+0.309	+0.208	<.001	.001	3	4
BRCA	NOP9 →	-0.281	-0.166	<.001	<.001	3	4
BRCA	ARHGAP32_S952 →	+0.655	+0.192	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 28,290 associations by consensus.

BIRC2 vs TRAF2 — LSCC

Explore this scatter interactively →