BIRC2

Across TCGA patient cohorts, BIRC2 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BIRC2-associated genes across cancer lineages are EGFR_pY1068, EGFR, and HER2_pY1248. Each is linked with BIRC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BIRC2-to-partner and partner-to-BIRC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by BIRC2-low versus BIRC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BIRC2→partner) and Y-score (partner→BIRC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.271	-2.584	.004	.001	3	1
UCEC	EGFR →	-0.122	-1.678	.047	.023	3	1
UCEC	HER2_pY1248 →	-0.209	-2.584	.041	.001	3	1
UCEC	INPP4B →	-0.310	-3.459	.012	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.177	-2.000	.006	.030	3	1
UCEC	JNK2 →	+0.180	+1.678	.018	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

EGFR_pY1068 by BIRC2 expression — UCEC

Explore this box plot interactively →