BIRC2

Across TCGA cell cohorts, BIRC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,464 significant associations in total. BONE shows the largest number of these associations.

The most reproducible BIRC2-associated GO terms across cancer lineages are Positive regulation of protein K48-linked ubiquitination, Regulation of protein monoubiquitination, and Positive regulation of protein monoubiquitination. Each is linked with BIRC2 in more than 18 cancer types. Because this analysis shows association rather than direction, both BIRC2-to-partner and partner-to-BIRC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of protein K48-linked ubiquitination grouped by BIRC2-low versus BIRC2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BIRC2→partner) and Y-score (partner→BIRC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of protein K48-linked ubiquitination →	+0.227	+2.120	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Regulation of protein monoubiquitination →	+0.201	+1.832	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Positive regulation of protein monoubiquitination →	+0.201	+1.832	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Regulation of protein K48-linked ubiquitination →	+0.201	+2.098	<.001	<.001	3	19
BREAST	Positive regulation of protein K63-linked ubiquitination →	+0.199	+1.062	<.001	<.001	3	18
LUNG_NSCLC_LUSC	Response to bleomycin →	+0.184	+1.782	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,464 associations by consensus.

Positive regulation of protein K48-linked ubiquitination by BIRC2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →