BIRC2

Across TCGA cell cohorts, BIRC2 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BIRC2-associated genes across cancer lineages are ECE2, PTH, and HTR1E. Each is linked with BIRC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BIRC2-to-partner and partner-to-BIRC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ECE2 grouped by BIRC2-low versus BIRC2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BIRC2→partner) and Y-score (partner→BIRC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ECE2 →	+0.323	+4.054	<.001	.004	3	1
LARGE_INTESTINE	PTH →	+0.049	+3.684	<.001	.006	3	1
LARGE_INTESTINE	HTR1E →	+0.085	+3.930	<.001	.003	3	1
LARGE_INTESTINE	ZBBX →	+0.127	+3.777	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ECE2 by BIRC2 expression — LARGE_INTESTINE

Explore this box plot interactively →