BIN3

Across TCGA pan-cancer cohorts, BIN3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated BIN3 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher BIN3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated BIN3 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

PDAC, UCEC, and OV are the cancer types where BIN3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.664	0.424	<.001	67	view →
UCEC	DFS	Tertile	All	0.971	0.797	.003	12	view →
OV	DFS	Quartile	All	0.654	0.973	.045	8	view →
HNSC	OS	Tertile	II,III,IV	0.923	0.779	.021	6	view →
CCRCC	OS	Quartile	All	1.000	0.856	.028	6	view →
LUAD	DFS	Median	III,IV	0.432	0.925	.047	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

BIN3–PDAC (OS)

Open the PDAC breakdown →