BIN3

Across TCGA patient cohorts, BIN3 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,162 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible BIN3-associated GO terms across cancer lineages are Protein poly-ADP-ribosylation, Positive regulation of DNA damage checkpoint, and RNA-templated DNA biosynthetic process. Each is linked with BIN3 in more than 27 cancer types. Because this analysis shows association rather than direction, both BIN3-to-partner and partner-to-BIN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein poly-ADP-ribosylation grouped by BIN3-low versus BIN3-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BIN3→partner) and Y-score (partner→BIN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Protein poly-ADP-ribosylation →	+0.153	+0.686	<.001	<.001	3	27
SCLC	Positive regulation of DNA damage checkpoint →	+0.076	+0.588	.001	<.001	2	28
SCLC	RNA-templated DNA biosynthetic process →	+0.070	+0.630	.001	<.001	3	26
UCS	Vacuole fusion →	+0.071	+0.687	<.001	<.001	2	26
THYM	ESCRT complex disassembly →	+0.066	+0.634	<.001	<.001	3	25
SCLC	Regulation of DNA biosynthetic process →	+0.044	+0.459	.002	.001	3	25

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,162 associations by consensus.

Protein poly-ADP-ribosylation by BIN3 expression — SCLC

Explore this box plot interactively →