BIN3

Across TCGA patient cohorts, BIN3 protein abundance is significantly associated with the RNA expression of many other genes, with 17,882 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible BIN3-associated genes across cancer lineages are ARHGEF37, SH2D4A, and FOXM1. Each is linked with BIN3 in more than 8 cancer types. Because this analysis shows association rather than direction, both BIN3-to-partner and partner-to-BIN3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BIN3 versus ARHGEF37 in BRCA, with a Pearson correlation of 0.59.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BIN3→partner) and Y-score (partner→BIN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ARHGEF37 →	+1.158	+0.448	<.001	<.001	3	9
BRCA	SH2D4A →	+1.017	+0.489	<.001	<.001	3	6
BRCA	FOXM1 →	-1.043	-0.344	<.001	<.001	3	6
UCEC	SGO1 →	-0.774	-0.337	<.001	<.001	3	6
BRCA	PSAT1 →	-2.095	-0.410	<.001	<.001	3	6
OV	FUT2 →	+1.042	+0.320	.005	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,882 associations by consensus.

BIN3 vs ARHGEF37 — BRCA

Explore this scatter interactively →