BIN3

Across TCGA patient cohorts, BIN3 mutation is significantly associated with the RNA expression of many other genes, with 136 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BIN3-associated genes across cancer lineages are RNVU1-28, TRAJ50, and RN7SL679P. Each is linked with BIN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both BIN3-to-partner and partner-to-BIN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNVU1-28 grouped by BIN3-low versus BIN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BIN3→partner) and Y-score (partner→BIN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNVU1-28 →	+0.947	+3.442	<.001	.001	3	2
COAD	TRAJ50 →	+0.862	+4.893	<.001	.005	3	2
COAD	RN7SL679P →	+0.628	+5.665	<.001	<.001	3	2
CESC	RN7SL447P →	+0.183	+5.201	<.001	.007	3	2
BLCA	ABHD17AP9 →	+0.074	+7.640	<.001	.009	3	2
UCEC	RNU1-57P →	+0.307	+4.662	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 136 associations by consensus.

RNVU1-28 by BIN3 expression — UCEC

Explore this box plot interactively →