BIN3

Across TCGA patient cohorts, BIN3 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BIN3-associated genes across cancer lineages are EGFR_pY1173, GAPDH, and p38-MAPK_pT180_Y182. Each is linked with BIN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both BIN3-to-partner and partner-to-BIN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1173 grouped by BIN3-low versus BIN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BIN3→partner) and Y-score (partner→BIN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1173 →	+0.134	+3.026	.003	.019	3	1
UCEC	GAPDH →	+0.806	+3.000	.009	.037	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.729	-2.986	.005	.037	3	1
UCEC	Ku80 →	+0.447	+3.013	.001	.019	2	1
UCEC	EGFR_pY1068 →	-0.307	-3.000	.034	.037	1	1
UCEC	eIF4E →	+0.258	+3.000	.034	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

EGFR_pY1173 by BIN3 expression — UCEC

Explore this box plot interactively →