BIN3

Across TCGA cell cohorts, BIN3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,156 significant associations in total. CNS shows the largest number of these associations.

The most reproducible BIN3-associated GO terms across cancer lineages are Positive regulation of telomere capping, Regulation of telomere capping, and Vacuole fusion. Each is linked with BIN3 in more than 12 cancer types. Because this analysis shows association rather than direction, both BIN3-to-partner and partner-to-BIN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of telomere capping grouped by BIN3-low versus BIN3-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BIN3→partner) and Y-score (partner→BIN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Positive regulation of telomere capping →	+0.098	+1.250	<.001	<.001	3	13
URINARY_TRACT	Regulation of telomere capping →	+0.091	+0.848	.003	.001	3	12
LARGE_INTESTINE	Vacuole fusion →	+0.104	+1.052	<.001	<.001	3	10
SOFT_TISSUE	Protein-containing complex disassembly →	+0.056	+0.543	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Protein depolymerization →	+0.128	+0.963	.001	.002	3	10
BLOOD_Leukemia	Mitotic cytokinesis →	+0.042	+0.445	.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,156 associations by consensus.

Positive regulation of telomere capping by BIN3 expression — SKIN

Explore this box plot interactively →