BIN2

Across TCGA pan-cancer cohorts, BIN2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated BIN2 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher BIN2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated BIN2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LUAD, and COAD are the cancer types where BIN2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	1.000	0.449	.023	18	view →
LUAD	DFS	Median	II,III,IV	0.779	0.313	.027	12	view →
COAD	DFS	Quartile	All	0.843	1.000	.039	6	view →
PDAC	OS	Median	III,IV	0.537	1.000	.008	5	view →
LSCC	DFS	Quartile	All	0.815	0.267	.031	2	view →
CCRCC	DFS	Quartile	II,III,IV	1.000	0.898	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

BIN2–HNSC (OS)

Open the HNSC breakdown →