BIN2

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, BIN2 protein abundance is significantly associated with the RNA expression of many other genes, with 23,015 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible BIN2-associated genes across cancer lineages are CYTH4, NCF4, and CSF2RB. Each is linked with BIN2 in more than 8 cancer types. Because this analysis shows association rather than direction, both BIN2-to-partner and partner-to-BIN2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BIN2 versus CYTH4 in GBM, with a Pearson correlation of 0.76.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BIN2→partner) and Y-score (partner→BIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMCYTH4 →+1.030+0.749<.001<.00139
GBMNCF4 →+1.264+0.825<.001<.00139
GBMCSF2RB →+1.177+0.846<.001<.00139
BRCAIL2RB →+1.313+0.523<.001<.00139
BRCAGZMH →+1.381+0.533<.001<.00139
BRCASLA2 →+1.085+0.603<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 23,015 associations by consensus.

BIN2 vs CYTH4 — GBM

Per-sample scatter of BIN2 vs CYTH4 in GBM (Pearson r = 0.76).

Explore this scatter interactively →

Exploration