BIN2

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, BIN2 protein abundance is significantly associated with the protein abundance of many other proteins, with 36,594 significant associations in total. GBM shows the largest number of these associations.

The most reproducible BIN2-associated proteins across cancer lineages are ADA2, AIF1, and AIF1_S39. Each is linked with BIN2 in more than 8 cancer types. Because this analysis shows association rather than direction, both BIN2-to-partner and partner-to-BIN2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BIN2 versus ADA2 in UCEC, with a Pearson correlation of 0.71.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (BIN2→partner) and Y-score (partner→BIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECADA2 →+0.645+0.684<.001<.00139
GBMAIF1 →+0.921+0.752<.001<.00139
GBMAIF1_S39 →+0.990+0.706<.001<.00139
GBMAMPD3 →+0.770+0.816<.001<.00139
LSCCANKRD44 →+0.533+0.694<.001<.00139
UCECAPBB1IP →+0.811+0.875<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 36,594 associations by consensus.

BIN2 vs ADA2 — UCEC

Per-sample scatter of BIN2 vs ADA2 in UCEC (Pearson r = 0.71).

Explore this scatter interactively →

Exploration