BIN2

Across TCGA patient cohorts, BIN2 mutation is significantly associated with the RNA expression of many other genes, with 2,304 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BIN2-associated genes across cancer lineages are CDCA2, ATL3, and COPS2. Each is linked with BIN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both BIN2-to-partner and partner-to-BIN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDCA2 grouped by BIN2-low versus BIN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BIN2→partner) and Y-score (partner→BIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDCA2 →	+0.667	+2.238	.002	.006	3	3
UCEC	ATL3 →	+0.469	+2.818	.002	.001	3	3
UCEC	COPS2 →	+0.389	+1.947	.009	.003	3	3
UCEC	MSANTD3 →	+0.639	+2.332	<.001	<.001	3	3
UCEC	WDR76 →	+0.596	+1.947	.002	.003	3	3
UCEC	ADNP2 →	+0.631	+2.542	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,304 associations by consensus.

CDCA2 by BIN2 expression — UCEC

Explore this box plot interactively →