BIN2

Across TCGA patient cohorts, BIN2 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BIN2-associated genes across cancer lineages are 4E-BP1_pT70, Notch1, and ATM. Each is linked with BIN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BIN2-to-partner and partner-to-BIN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pT70 grouped by BIN2-low versus BIN2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BIN2→partner) and Y-score (partner→BIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	4E-BP1_pT70 →	+0.170	+2.815	.009	.036	3	2
UCEC	Notch1 →	+0.159	+2.710	.003	.003	3	2
UCEC	ATM →	-0.392	-3.308	.027	.009	3	2
UCEC	Caspase-8 →	-0.241	-3.432	.014	.005	3	2
UCEC	4E-BP1 →	+0.209	+2.321	.049	.033	3	2
UCEC	JNK_pT183_Y185 →	-0.168	-1.986	.011	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

4E-BP1_pT70 by BIN2 expression — COAD

Explore this box plot interactively →