BIN2

Across TCGA cell cohorts, BIN2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,959 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BIN2-associated GO terms across cancer lineages are Regulation of proteasomal ubiquitin-dependent protein catabolic process, Positive regulation of proteasomal ubiquitin-dependent protein catabolic process, and Regulation of proteasomal protein catabolic process. Each is linked with BIN2 in more than 6 cancer types. Because this analysis shows association rather than direction, both BIN2-to-partner and partner-to-BIN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of proteasomal ubiquitin-dependent protein catabolic process grouped by BIN2-low versus BIN2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BIN2→partner) and Y-score (partner→BIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of proteasomal ubiquitin-dependent protein catabolic process →	+0.054	+0.028	.004	.004	3	7
OESOPHAGUS	Positive regulation of proteasomal ubiquitin-dependent protein catabolic process →	+0.076	+0.087	<.001	<.001	3	7
OESOPHAGUS	Regulation of proteasomal protein catabolic process →	+0.101	+0.118	<.001	<.001	3	7
LUNG_SCLC	Regulation of synoviocyte proliferation →	-0.170	-0.065	.004	.002	2	6
LUNG_SCLC	Positive regulation of synoviocyte proliferation →	-0.170	-0.065	.004	.002	2	6
SKIN	Viral translational termination-reinitiation →	+0.076	+0.055	.003	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,959 associations by consensus.

Regulation of proteasomal ubiquitin-dependent protein catabolic process by BIN2 expression — BONE

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