BIN1

Across TCGA pan-cancer cohorts, BIN1 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated BIN1 data layer compared with 23 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher BIN1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated BIN1 expression acts as an unfavorable survival marker.

CESC, BRCA, and READ are the cancer types where BIN1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	II,III,IV	0.068	0.830	<.001	30	view →
BRCA	OS	Median	III,IV	0.191	0.833	<.001	19	view →
READ	DFS	Median	All	0.182	0.819	.004	18	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
LUSC	OS	Median	III,IV	0.112	0.664	.003	12	view →
CHOL	OS	Median	III,IV	0.275	0.886	.045	6	view →
LGG	OS	Median	All	0.214	0.889	<.001	6	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
COAD	OS	Median	III,IV	0.159	0.692	.021	6	view →
GBM	DFS	Median	All	0.031	0.243	<.001	3	view →
BLCA	DFS	Median	IV	0.146	0.471	.030	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

BIN1–CESC (OS)

Open the CESC breakdown →