BIN1

Across TCGA pan-cancer cohorts, BIN1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated BIN1 data layer compared with 23 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher BIN1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated BIN1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and COAD show a favorable association.

LSCC, CCRCC, and COAD are the cancer types where BIN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	II,III,IV	0.573	0.957	<.001	59	view →
CCRCC	DFS	Median	III,IV	0.985	0.144	.008	32	view →
COAD	DFS	Median	All	1.000	0.920	.015	30	view →
LUAD	DFS	Tertile	All	0.746	0.500	.012	12	view →
PDAC	OS	Median	All	0.458	0.296	.016	5	view →
GBM	OS	Quartile	All	0.260	0.625	.016	2	view →
HNSC	DFS	Median	III,IV	1.000	0.939	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

BIN1–LSCC (OS)

Open the LSCC breakdown →