BIN1

Across TCGA patient cohorts, BIN1 mutation is significantly associated with the RNA expression of many other genes, with 3,864 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BIN1-associated genes across cancer lineages are APCDD1, AK8, and NDRG2. Each is linked with BIN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BIN1-to-partner and partner-to-BIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, APCDD1 grouped by BIN1-low versus BIN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BIN1→partner) and Y-score (partner→BIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	APCDD1 →	-0.955	-2.237	.001	.001	3	2
UCEC	AK8 →	-0.596	-2.796	.005	.003	3	2
UCEC	NDRG2 →	-0.945	-1.983	<.001	<.001	3	2
UCEC	FAM214B →	+0.300	+1.807	.002	.004	3	2
LUAD	SLC5A4P1 →	+0.091	+4.984	<.001	.005	3	2
LUAD	OR8Q1P →	+0.544	+5.157	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,864 associations by consensus.

APCDD1 by BIN1 expression — UCEC

Explore this box plot interactively →