BIN1

Across TCGA cell cohorts, BIN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,363 significant associations in total. BONE shows the largest number of these associations.

The most reproducible BIN1-associated GO terms across cancer lineages are T-tubule organization, Negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel, and Negative regulation of action potential. Each is linked with BIN1 in more than 18 cancer types. Because this analysis shows association rather than direction, both BIN1-to-partner and partner-to-BIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, T-tubule organization grouped by BIN1-low versus BIN1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BIN1→partner) and Y-score (partner→BIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	T-tubule organization →	+1.753	+2.963	<.001	<.001	3	19
BONE	Negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel →	+0.348	+2.874	.008	<.001	3	14
OVARY	Negative regulation of action potential →	+0.328	+1.928	<.001	<.001	3	12
LUNG_SCLC	Regulation of astrocyte differentiation →	+0.144	+2.185	.002	.002	3	12
SOFT_TISSUE	Negative regulation of cardiac muscle contraction →	+0.283	+1.760	<.001	<.001	3	12
BONE	Positive regulation of cell-substrate junction organization →	+0.142	+1.948	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,363 associations by consensus.

T-tubule organization by BIN1 expression — BREAST

Explore this box plot interactively →