BIN1

Across TCGA cell cohorts, BIN1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BIN1-associated genes across cancer lineages are SDHB, TMEM235, and STH. Each is linked with BIN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BIN1-to-partner and partner-to-BIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SDHB grouped by BIN1-low versus BIN1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BIN1→partner) and Y-score (partner→BIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SDHB →	+0.537	+3.180	.004	.004	3	1
LARGE_INTESTINE	TMEM235 →	+0.005	+2.560	.005	.008	3	1
LARGE_INTESTINE	STH →	+0.135	+3.054	<.001	.001	3	1
LARGE_INTESTINE	VDAC3 →	+0.778	+3.082	<.001	.007	3	1
BLOOD_Lymphoma	TMEM61 →	+0.061	+4.192	<.001	.003	3	1
BLOOD_Lymphoma	SHCBP1L →	+0.031	+3.843	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

SDHB by BIN1 expression — LARGE_INTESTINE

Explore this box plot interactively →