BID

Across TCGA patient cohorts, BID mutation is significantly associated with the RNA expression of many other genes, with 1,422 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BID-associated genes across cancer lineages are AP1S2P1, SOD1P2, and NPAP1P2. Each is linked with BID in more than 1 cancer types. Because this analysis shows association rather than direction, both BID-to-partner and partner-to-BID results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AP1S2P1 grouped by BID-low versus BID-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BID→partner) and Y-score (partner→BID) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	AP1S2P1 →	+0.173	+4.594	<.001	.008	3	2
COAD	SOD1P2 →	+0.369	+5.145	<.001	.007	3	2
UCEC	NPAP1P2 →	+0.037	+2.438	<.001	.005	3	2
UCEC	RNA5SP413 →	+1.355	+2.277	<.001	.004	3	2
UCEC	IGLV2-8 →	+2.101	+3.700	<.001	.001	3	1
SKCM	RPL7L1P5 →	+0.124	+4.324	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,422 associations by consensus.

AP1S2P1 by BID expression — SKCM

Explore this box plot interactively →