BID

Across TCGA patient cohorts, BID mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BID-associated genes across cancer lineages are SF2, EGFR_pY1068, and eIF4E. Each is linked with BID in more than 1 cancer types. Because this analysis shows association rather than direction, both BID-to-partner and partner-to-BID results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SF2 grouped by BID-low versus BID-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BID→partner) and Y-score (partner→BID) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SF2 →	-0.170	-2.308	.001	.036	3	2
UCEC	EGFR_pY1068 →	-0.337	-3.459	.007	.005	3	1
UCEC	eIF4E →	+0.237	+2.321	.025	.035	3	1
UCEC	ACVRL1 →	-0.200	-3.150	.003	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.252	-3.169	.002	.019	3	1
UCEC	Ku80 →	+0.303	+2.817	.010	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

SF2 by BID expression — UCEC

Explore this box plot interactively →