BICRA

Across TCGA patient cohorts, BICRA protein abundance is significantly associated with the RNA expression of many other genes, with 6,650 significant associations in total. GBM shows the largest number of these associations.

The most reproducible BICRA-associated genes across cancer lineages are SQSTM1, PPP5C, and RPL39P16. Each is linked with BICRA in more than 3 cancer types. Because this analysis shows association rather than direction, both BICRA-to-partner and partner-to-BICRA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BICRA versus SQSTM1 in OV, with a Pearson correlation of -0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BICRA→partner) and Y-score (partner→BICRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SQSTM1 →	-0.700	-0.417	.001	<.001	3	4
GBM	PPP5C →	+0.442	+0.361	.001	<.001	3	4
OV	RPL39P16 →	+1.089	+0.397	<.001	.002	3	3
GBM	SIGLEC9 →	-1.144	-0.372	<.001	<.001	3	3
GBM	MISP3 →	+0.645	+0.398	<.001	<.001	3	3
PDAC	MSN →	-0.610	-0.364	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,650 associations by consensus.

BICRA vs SQSTM1 — OV

Explore this scatter interactively →