BICRA

Across TCGA patient cohorts, BICRA mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BICRA-associated genes across cancer lineages are p70-S6K, PDCD4, and C-Raf. Each is linked with BICRA in more than 1 cancer types. Because this analysis shows association rather than direction, both BICRA-to-partner and partner-to-BICRA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p70-S6K grouped by BICRA-low versus BICRA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BICRA→partner) and Y-score (partner→BICRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p70-S6K →	+0.189	+2.114	.010	.003	3	2
UCEC	PDCD4 →	-0.485	-2.321	.007	.033	3	2
UCEC	C-Raf →	+0.204	+2.222	<.001	.010	3	2
COAD	MYH11 →	-1.478	-3.313	.015	.010	3	1
COAD	PTEN →	+0.148	+2.178	.025	.035	3	1
UCEC	eEF2 →	+0.355	+2.087	.009	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

p70-S6K by BICRA expression — UCEC

Explore this box plot interactively →