BICRA

Across TCGA cell cohorts, BICRA mutation is significantly associated with the RNA expression of many other genes, with 1,284 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BICRA-associated genes across cancer lineages are LYG1, FAM205A, and FBXL4. Each is linked with BICRA in more than 2 cancer types. Because this analysis shows association rather than direction, both BICRA-to-partner and partner-to-BICRA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYG1 grouped by BICRA-low versus BICRA-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BICRA→partner) and Y-score (partner→BICRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LYG1 →	+1.049	+2.850	<.001	<.001	3	3
OVARY	FAM205A →	+0.053	+3.129	<.001	.001	3	3
LARGE_INTESTINE	FBXL4 →	+0.399	+2.158	.005	.004	3	3
LARGE_INTESTINE	NAE1 →	+0.590	+2.244	<.001	.003	3	3
LARGE_INTESTINE	TTC39C →	+0.750	+3.321	.002	.003	3	3
LARGE_INTESTINE	ACADSB →	+0.662	+2.158	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,284 associations by consensus.

LYG1 by BICRA expression — LARGE_INTESTINE

Explore this box plot interactively →