BICDL1

Across TCGA patient cohorts, BICDL1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BICDL1-associated genes across cancer lineages are Cyclin-B1, GAPDH, and TAZ. Each is linked with BICDL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both BICDL1-to-partner and partner-to-BICDL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by BICDL1-low versus BICDL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BICDL1→partner) and Y-score (partner→BICDL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.443	+3.169	.044	.018	3	3
COAD	GAPDH →	+1.219	+3.008	<.001	.019	2	3
COAD	TAZ →	+0.215	+2.832	.035	.034	3	2
UCEC	STAT3_pY705 →	-0.351	-3.690	<.001	.001	3	2
UCEC	ASNS →	+0.516	+2.807	<.001	.003	3	2
COAD	NF-kB-p65_pS536 →	-0.620	-2.991	.024	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Cyclin-B1 by BICDL1 expression — UCEC

Explore this box plot interactively →