BICDL1

Across TCGA cell cohorts, BICDL1 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible BICDL1-associated genes across cancer lineages are TOPAZ1, ASB17, and C12orf40. Each is linked with BICDL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BICDL1-to-partner and partner-to-BICDL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TOPAZ1 grouped by BICDL1-low versus BICDL1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BICDL1→partner) and Y-score (partner→BICDL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TOPAZ1 →	+0.166	+5.357	<.001	.003	3	1
OVARY	ASB17 →	+0.017	+4.807	<.001	.003	3	1
OVARY	C12orf40 →	+0.011	+4.029	<.001	.009	3	1
CNS	ICOS →	+0.020	+3.774	<.001	.008	3	1
CNS	SPATA48 →	+0.022	+4.772	<.001	.002	3	1
SKIN	SEMG2 →	+0.008	+3.632	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

TOPAZ1 by BICDL1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →