BICDL1

Across TCGA cell cohorts, BICDL1 mutation is significantly associated with the mutation status of many other genes, with 4,609 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BICDL1-associated genes across cancer lineages are GRIA2, RAPGEF4, and NFIC. Each is linked with BICDL1 in more than 4 cancer types. Because this analysis shows association rather than direction, both BICDL1-to-partner and partner-to-BICDL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GRIA2 grouped by BICDL1-low versus BICDL1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BICDL1→partner) and Y-score (partner→BICDL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	GRIA2 →	+4.977	+4.415	.007	.007	1	5
CNS	RAPGEF4 →	+4.277	+4.584	.001	.001	1	4
LARGE_INTESTINE	NFIC →	+4.744	+5.459	<.001	<.001	1	4
CNS	RUNX1 →	+5.277	+4.459	.005	.005	1	4
LUNG_NSCLC_LUAD	ADAMTS15 →	+4.187	+5.000	.008	.008	1	4
LUNG_NSCLC_LUAD	PCCA →	+4.772	+5.339	.004	.004	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,609 associations by consensus.

GRIA2 by BICDL1 expression — OVARY

Explore this box plot interactively →