BICC1

Across TCGA patient cohorts, BICC1 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BICC1-associated genes across cancer lineages are Cyclin-B1, G6PD, and ACC1. Each is linked with BICC1 in more than 3 cancer types. Because this analysis shows association rather than direction, both BICC1-to-partner and partner-to-BICC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by BICC1-low versus BICC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BICC1→partner) and Y-score (partner→BICC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.759	+1.999	<.001	<.001	3	4
LUSC	G6PD →	+0.698	+2.816	.005	.036	3	3
STAD	ACC1 →	+0.696	+2.342	<.001	.019	3	3
LUAD	Fibronectin →	+0.952	+3.000	<.001	.034	3	3
STAD	TIGAR →	+0.558	+3.000	.002	.034	2	4
UCEC	ATM →	-0.502	-1.986	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

Cyclin-B1 by BICC1 expression — UCEC

Explore this box plot interactively →