BHMT2

Across TCGA cell cohorts, BHMT2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,384 significant associations in total. BONE shows the largest number of these associations.

The most reproducible BHMT2-associated GO terms across cancer lineages are Protein exit from endoplasmic reticulum, Regulation of extrinsic apoptotic signaling pathway via death domain receptors, and Cotranslational protein targeting to membrane. Each is linked with BHMT2 in more than 6 cancer types. Because this analysis shows association rather than direction, both BHMT2-to-partner and partner-to-BHMT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein exit from endoplasmic reticulum grouped by BHMT2-low versus BHMT2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BHMT2→partner) and Y-score (partner→BHMT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Protein exit from endoplasmic reticulum →	+0.112	+1.074	<.001	.008	3	7
LIVER	Regulation of extrinsic apoptotic signaling pathway via death domain receptors →	+0.123	+4.237	.007	<.001	3	6
LIVER	Cotranslational protein targeting to membrane →	+0.114	+4.223	.004	<.001	3	6
LIVER	Establishment of protein localization to endoplasmic reticulum →	+0.105	+3.938	<.001	.001	2	7
KIDNEY	Amino-acid betaine catabolic process →	+1.313	+4.461	<.001	<.001	3	6
BLOOD_Lymphoma	Protein K63-linked ubiquitination →	+0.036	+0.106	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,384 associations by consensus.

Protein exit from endoplasmic reticulum by BHMT2 expression — BONE

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