BHMT2

Across TCGA cell cohorts, BHMT2 mutation is significantly associated with the drug of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BHMT2-associated genes across cancer lineages are Rucaparib, 50869, and Bromosporine. Each is linked with BHMT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BHMT2-to-partner and partner-to-BHMT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rucaparib grouped by BHMT2-low versus BHMT2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BHMT2→partner) and Y-score (partner→BHMT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Rucaparib →	+0.330	+2.710	.036	.043	3	1
LARGE_INTESTINE	50869 →	+0.516	+2.649	.013	.046	2	1
LARGE_INTESTINE	Bromosporine →	+0.428	+2.649	.012	.046	1	1
LARGE_INTESTINE	Entospletinib →	+0.571	+2.646	.002	.047	1	1
LARGE_INTESTINE	Elephantin →	+0.474	+2.777	.015	.038	1	1
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.761	+2.646	.001	.047	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Rucaparib by BHMT2 expression — LARGE_INTESTINE

Explore this box plot interactively →