BHMT

Across TCGA pan-cancer cohorts, BHMT mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated BHMT data layer compared with 22 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher BHMT mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated BHMT expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

CCRCC, LSCC, and GBM are the cancer types where BHMT mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	All	1.000	0.821	.017	10	view →
LSCC	DFS	Median	II,III,IV	0.612	1.000	.034	5	view →
GBM	OS	Median	All	0.541	0.327	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

BHMT–CCRCC (OS)

Open the CCRCC breakdown →