BHMT

Across TCGA patient cohorts, BHMT mutation is significantly associated with the RNA expression of many other genes, with 1,250 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BHMT-associated genes across cancer lineages are RNA5SP262, TTTY2B, and CCL18. Each is linked with BHMT in more than 2 cancer types. Because this analysis shows association rather than direction, both BHMT-to-partner and partner-to-BHMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP262 grouped by BHMT-low versus BHMT-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BHMT→partner) and Y-score (partner→BHMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	RNA5SP262 →	+0.332	+3.929	.001	.005	3	3
HNSC	TTTY2B →	+0.009	+7.954	<.001	.008	3	2
UCEC	CCL18 →	+1.327	+3.815	<.001	<.001	3	2
UCEC	LRRK1 →	-0.443	-2.898	.005	.001	3	2
UCEC	PKN3 →	+0.655	+2.354	<.001	.003	3	2
UCEC	DTYMK →	+0.606	+2.386	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,250 associations by consensus.

RNA5SP262 by BHMT expression — STAD

Explore this box plot interactively →