BHMT

Across TCGA patient cohorts, BHMT mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BHMT-associated genes across cancer lineages are ATM, eEF2, and eIF4E. Each is linked with BHMT in more than 1 cancer types. Because this analysis shows association rather than direction, both BHMT-to-partner and partner-to-BHMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by BHMT-low versus BHMT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BHMT→partner) and Y-score (partner→BHMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.617	-3.584	<.001	.002	3	2
UCEC	eEF2 →	+0.373	+3.321	.006	.009	3	1
UCEC	eIF4E →	+0.230	+2.584	.004	.001	3	1
UCEC	A-Raf_pS299 →	-0.121	-3.459	.008	.005	3	1
UCEC	FoxM1 →	+0.269	+2.584	.006	.001	3	1
UCEC	FOXO3a_pS318_S321 →	-0.118	-2.212	.013	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

ATM by BHMT expression — UCEC

Explore this box plot interactively →