BHLHE23

Across TCGA cell cohorts, BHLHE23 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. CNS shows the largest number of these associations.

The most reproducible BHLHE23-associated genes across cancer lineages are DBX2, PTH, and PABPC1L2A. Each is linked with BHLHE23 in more than 1 cancer types. Because this analysis shows association rather than direction, both BHLHE23-to-partner and partner-to-BHLHE23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DBX2 grouped by BHLHE23-low versus BHLHE23-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BHLHE23→partner) and Y-score (partner→BHLHE23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DBX2 →	+0.023	+4.977	<.001	.007	3	1
CNS	PTH →	+0.299	+5.754	<.001	.002	3	1
CNS	PABPC1L2A →	+0.055	+5.321	<.001	.005	3	1
CNS	GALP →	+1.537	+4.981	<.001	.008	3	1
CNS	TMEM235 →	+0.085	+5.321	<.001	.005	3	1
CNS	TIFAB →	+0.006	+4.981	.007	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

DBX2 by BHLHE23 expression — LARGE_INTESTINE

Explore this box plot interactively →