BHLHE22

Across TCGA patient cohorts, BHLHE22 mutation is significantly associated with the total protein of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BHLHE22-associated genes across cancer lineages are c-Met_pY1235, PDCD4, and Shc_pY317. Each is linked with BHLHE22 in more than 2 cancer types. Because this analysis shows association rather than direction, both BHLHE22-to-partner and partner-to-BHLHE22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by BHLHE22-low versus BHLHE22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BHLHE22→partner) and Y-score (partner→BHLHE22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.078	+2.232	.004	.005	3	3
UCEC	PDCD4 →	-0.613	-3.321	<.001	.009	3	2
UCEC	Shc_pY317 →	-0.215	-3.700	<.001	.001	3	2
COAD	Smad4 →	+0.190	+3.000	.003	.034	3	2
COAD	E-Cadherin →	-0.851	-3.161	.006	.019	3	2
UCEC	mTOR_pS2448 →	-0.127	-1.861	.022	.049	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

c-Met_pY1235 by BHLHE22 expression — UCEC

Explore this box plot interactively →