BHLHE22

Across TCGA cell cohorts, BHLHE22 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,007 significant associations in total. BONE shows the largest number of these associations.

The most reproducible BHLHE22-associated GO terms across cancer lineages are Epigenetic regulation of gene expression, Nuclear export, and Regulation of nucleotide-excision repair. Each is linked with BHLHE22 in more than 7 cancer types. Because this analysis shows association rather than direction, both BHLHE22-to-partner and partner-to-BHLHE22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epigenetic regulation of gene expression grouped by BHLHE22-low versus BHLHE22-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BHLHE22→partner) and Y-score (partner→BHLHE22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Epigenetic regulation of gene expression →	+0.046	+2.134	.007	.002	2	8
BONE	Nuclear export →	+0.060	+2.346	.007	.003	3	6
LUNG_SCLC	Regulation of nucleotide-excision repair →	+0.096	+2.396	.001	.001	3	5
BONE	Transcription initiation at RNA polymerase II promoter →	+0.086	+3.412	.001	<.001	3	5
BONE	Lactam metabolic process →	-1.327	-2.629	.001	.002	3	5
BLOOD_Leukemia	Regulation of TORC1 signaling →	+0.025	+1.144	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,007 associations by consensus.

Epigenetic regulation of gene expression by BHLHE22 expression — LUNG_SCLC

Explore this box plot interactively →