BHLHE22

Across TCGA cell cohorts, BHLHE22 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BHLHE22-associated genes across cancer lineages are FAM170B, CHCHD4, and RRH. Each is linked with BHLHE22 in more than 1 cancer types. Because this analysis shows association rather than direction, both BHLHE22-to-partner and partner-to-BHLHE22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM170B grouped by BHLHE22-low versus BHLHE22-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BHLHE22→partner) and Y-score (partner→BHLHE22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FAM170B →	+0.138	+4.981	<.001	.008	3	1
LARGE_INTESTINE	CHCHD4 →	+0.564	+3.067	.006	.009	3	1
LARGE_INTESTINE	RRH →	+0.232	+3.295	.001	.006	3	1
LARGE_INTESTINE	RPE →	+0.435	+3.160	.003	.006	3	1
LARGE_INTESTINE	ZFP2 →	+0.576	+3.082	<.001	.007	3	1
LARGE_INTESTINE	DAZ4 →	+0.109	+2.977	.008	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

FAM170B by BHLHE22 expression — CNS

Explore this box plot interactively →