BHLHA15

Across TCGA patient cohorts, BHLHA15 mutation is significantly associated with the RNA expression of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BHLHA15-associated genes across cancer lineages are LINC02546, RPL31P9, and DEFB104A. Each is linked with BHLHA15 in more than 1 cancer types. Because this analysis shows association rather than direction, both BHLHA15-to-partner and partner-to-BHLHA15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02546 grouped by BHLHA15-low versus BHLHA15-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BHLHA15→partner) and Y-score (partner→BHLHA15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	LINC02546 →	+0.063	+5.812	<.001	.003	3	2
UCEC	RPL31P9 →	+0.284	+4.132	<.001	.009	3	2
UCEC	DEFB104A →	+0.106	+5.414	<.001	.001	3	1
UCEC	FXNP2 →	+0.246	+3.776	.007	.006	3	1
COAD	MIR1263 →	+1.494	+7.741	<.001	.009	3	1
COAD	MIR1283-1 →	+0.726	+7.741	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

LINC02546 by BHLHA15 expression — CESC

Explore this box plot interactively →