BHLHA15

Across TCGA cell cohorts, BHLHA15 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,736 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BHLHA15-associated GO terms across cancer lineages are Protein targeting to ER, Establishment of protein localization to endoplasmic reticulum, and SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Each is linked with BHLHA15 in more than 11 cancer types. Because this analysis shows association rather than direction, both BHLHA15-to-partner and partner-to-BHLHA15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein targeting to ER grouped by BHLHA15-low versus BHLHA15-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BHLHA15→partner) and Y-score (partner→BHLHA15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Protein targeting to ER →	+0.127	+1.598	<.001	<.001	3	12
PANCREAS	Establishment of protein localization to endoplasmic reticulum →	+0.113	+1.525	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition →	+0.130	+1.101	<.001	<.001	3	10
LIVER	Protein exit from endoplasmic reticulum →	+0.105	+1.742	.003	.002	3	10
UPPER_AERODIGESTIVE_TRACT	Negative regulation of mRNA metabolic process →	+0.055	+0.797	<.001	<.001	3	9
BLOOD_Lymphoma	Post-translational protein targeting to endoplasmic reticulum membrane →	+0.092	+1.154	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,736 associations by consensus.

Protein targeting to ER by BHLHA15 expression — PANCREAS

Explore this box plot interactively →