BFSP2

Across TCGA patient cohorts, BFSP2 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BFSP2-associated genes across cancer lineages are Notch1, MSH2, and TFRC. Each is linked with BFSP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BFSP2-to-partner and partner-to-BFSP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by BFSP2-low versus BFSP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BFSP2→partner) and Y-score (partner→BFSP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.164	+2.820	.009	.035	3	2
UCEC	MSH2 →	-0.269	-3.295	.009	.009	3	1
UCEC	TFRC →	+0.517	+2.000	.030	.032	3	1
UCEC	Chk2 →	-0.300	-2.700	.004	.006	3	1
UCEC	Annexin-1 →	+0.840	+2.700	<.001	.006	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Notch1 by BFSP2 expression — UCEC

Explore this box plot interactively →