BFSP2

Across TCGA cell cohorts, BFSP2 mutation is significantly associated with the drug of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BFSP2-associated genes across cancer lineages are Uprosertib, I-BET-762, and Entospletinib. Each is linked with BFSP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BFSP2-to-partner and partner-to-BFSP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Uprosertib grouped by BFSP2-low versus BFSP2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BFSP2→partner) and Y-score (partner→BFSP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Uprosertib →	+0.598	+2.646	.048	.047	3	1
LARGE_INTESTINE	I-BET-762 →	+0.605	+2.646	.012	.047	3	1
LARGE_INTESTINE	Entospletinib →	+0.409	+2.646	.033	.047	3	1
LARGE_INTESTINE	PAK_5339 →	+0.298	+2.678	.046	.037	3	1
LARGE_INTESTINE	Dactinomycin →	+0.515	+2.649	.028	.046	3	1
LARGE_INTESTINE	Vincristine →	+0.941	+2.649	.029	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Uprosertib by BFSP2 expression — LARGE_INTESTINE

Explore this box plot interactively →