BFSP1

Across TCGA patient cohorts, BFSP1 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BFSP1-associated genes across cancer lineages are Caspase-8, FASN, and MEK1. Each is linked with BFSP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both BFSP1-to-partner and partner-to-BFSP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by BFSP1-low versus BFSP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BFSP1→partner) and Y-score (partner→BFSP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.264	-3.780	.005	<.001	3	3
UCEC	FASN →	+0.323	+2.000	.029	.030	3	2
UCEC	MEK1 →	+0.448	+3.321	.001	.009	3	2
UCEC	NDRG1_pT346 →	-0.392	-1.415	.033	.046	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.369	-1.700	.028	.042	3	2
UCEC	EGFR_pY1068 →	-0.255	-1.700	.006	.040	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Caspase-8 by BFSP1 expression — UCEC

Explore this box plot interactively →