BFAR

Across TCGA patient cohorts, BFAR mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BFAR-associated genes across cancer lineages are Caspase-7-cleavedD198, Chk2_pT68, and A-Raf_pS299. Each is linked with BFAR in more than 2 cancer types. Because this analysis shows association rather than direction, both BFAR-to-partner and partner-to-BFAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by BFAR-low versus BFAR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BFAR→partner) and Y-score (partner→BFAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.590	+2.479	.011	.010	3	3
UCEC	Chk2_pT68 →	-0.147	-1.584	.044	.036	3	3
UCEC	A-Raf_pS299 →	-0.156	-2.000	<.001	.010	3	2
UCEC	PCNA →	+0.220	+2.999	.009	.035	3	2
UCEC	ASNS →	+0.364	+3.169	.010	.018	3	2
UCEC	14-3-3_beta →	-0.121	-2.564	.002	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Caspase-7-cleavedD198 by BFAR expression — UCEC

Explore this box plot interactively →