BFAR

Across TCGA cell cohorts, BFAR mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible BFAR-associated genes across cancer lineages are TGM6, ASB17, and C12orf40. Each is linked with BFAR in more than 1 cancer types. Because this analysis shows association rather than direction, both BFAR-to-partner and partner-to-BFAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TGM6 grouped by BFAR-low versus BFAR-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BFAR→partner) and Y-score (partner→BFAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TGM6 →	+0.030	+6.569	<.001	<.001	3	1
OVARY	ASB17 →	+0.017	+4.807	<.001	.003	3	1
OVARY	C12orf40 →	+0.011	+4.029	<.001	.009	3	1
OVARY	OR11H2 →	+0.046	+4.450	.002	.004	3	1
LARGE_INTESTINE	ACSM6 →	+0.019	+3.658	.002	.005	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

TGM6 by BFAR expression — BLOOD_Leukemia

Explore this box plot interactively →