BFAR

Across TCGA cell cohorts, BFAR mutation is significantly associated with the mutation status of many other genes, with 3,201 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BFAR-associated genes across cancer lineages are RNF31, PLD2, and KMT5C. Each is linked with BFAR in more than 2 cancer types. Because this analysis shows association rather than direction, both BFAR-to-partner and partner-to-BFAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNF31 grouped by BFAR-low versus BFAR-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BFAR→partner) and Y-score (partner→BFAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RNF31 →	+4.562	+5.217	<.001	<.001	1	3
OVARY	PLD2 →	+5.562	+5.562	<.001	<.001	1	3
BLOOD_Leukemia	KMT5C →	+4.000	+5.050	.008	.008	1	3
BLOOD_Leukemia	PADI3 →	+4.321	+5.285	.005	.005	1	3
OVARY	GMPPA →	+4.977	+4.415	.007	.007	1	3
BLOOD_Leukemia	KCNA6 →	+4.000	+5.050	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,201 associations by consensus.

RNF31 by BFAR expression — OVARY

Explore this box plot interactively →