Across TCGA patient cohorts, BEX5 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BEX5-associated genes across cancer lineages are GATA6, HER3, and p38-MAPK. Each is linked with BEX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both BEX5-to-partner and partner-to-BEX5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BEX5→partner) and Y-score (partner→BEX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GATA6 →	-0.176	-2.992	.048	.036	3	1
UCEC	HER3 →	+0.568	+3.183	<.001	.010	3	1
UCEC	p38-MAPK →	-0.220	-3.169	.014	.020	3	1
UCEC	Annexin_VII →	-0.152	-2.990	.046	.036	3	1
UCEC	STAT3_pY705 →	-0.558	-3.169	<.001	.020	3	1
UCEC	VHL →	-1.010	-3.169	.006	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

BEX5 survival (RNA) · tumor vs normal (RNA) · all BEX5 data types